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From a pathological perspective, SLE often exhibits a hypoxic state in local tissues due to abnormal activation of T and B cells, sustained (148)

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192,193 This suppression of effector T cell responses may be partly mediated by TGF-β-induced transcriptional changes, leading to changes in the expression of key transcription factors such as T-bet and Eomes, 194,195 which are essential for maintaining T cell function