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Figure 5 Overall, these results show that a 3-month clinical intervention of L-GSH supplementation in individuals with T2DM resulted in significantly increased levels of IFN-γ, TNF-α, IL-2, and decreased levels of IL-10 when compared to before L-GSH supplementation
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7.3 Ongoing challenges and future directions The translation of ferroptosis-targeted therapies faces several significant challenges that require careful consideration: 7.3.1 Nanocarrier delivery challenges While nanocarriers offer promising targeting capabilities, they face substantial translational hurdles including potential immunogenicity, nebulizer compatibility and stability, batch-to-batch consistency in manufacturing, and difficulties achieving uniform deep lung penetration and cellular uptake across different airway regions and cell types
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