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For instance, in male Sprague-Dawley rats, treatment with pyridoxamine improved survival after left anterior descending coronary artery (LAD) occlusion, lowered plasma AGE levels, reduced left ventricular end-diastolic pressure, and preserved diastolic function by limiting collagen accumulation, particularly cross-linked type I collagen in the peri-infarct region [159]
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Our results showed that during the demyelination process, the T 2 WI signal gradually changed to hyperintensity, which was accompanied by an increase in the T 2 -nor value
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