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10.1001/jama.2021.4788 [DOI] [PMC free article] [PubMed] [Google Scholar] Chen H., Wang S., Song M., Yang D., Li H

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How GHK-Cu Differs From BPC-157 and TB-500 GHK-Cu A three-amino-acid human peptide that carries a copper ion Studied mostly for skin, matrix remodeling, and wound-related signaling Has small topical human trials, with mixed and partly negative results No systemic randomized controlled trials in humans BPC-157 A 15-amino-acid sequence derived from a protein found in gastric juice Studied mostly in tendon, gut, and soft-tissue animal models Human data is limited to a case series with significant design flaws (PMID 41476424) Covered in depth in our BPC-157 article TB-500 A synthetic fragment corresponding to the active region of thymosin beta-4 Studied for cell migration and tissue repair in preclinical models The published human trial program tested the parent molecule, not the fragment Covered in depth in our TB-500 article Researchers reach for these three to ask different questions