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Moreover, sleep loss in mice leads to an increase in MEF2C dephosphorylation in the cortex, thus contributing to increased transcriptional activity ( RE-1 silencing transcription factor, a TF that represses neural genes in non-neuronal cell types, downregulates genes involved in pathogenic pathways, reduces inflammation, and increases remyelination in the brain (Huang et al., 2025
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Chronic ketamine use disrupts normal brain function and contributes to the development of addiction and other mental health disorders
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