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However, fetal weights were decreased and skeletal ossification was delayed in rats in association with maternal toxicity at the highest dose, with an AUC exposure at the no-effect dose that is 4.5-times the AUC exposure at an adult human dose of 100 mg per day
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Subsequently, CH2-THF undergoes demethylation by the action of SHMT1, reverting back to THF, which facilitates the conversion of glycine to serine and ensuring the regeneration of folate, maintaining its function in biochemical reactions [30]
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