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Given that AQP4-IgG is the primary driver of astrocyte damage in NMOSD, and previous research has underscored the critical role of IGF-2 in the CNS 18,19,20 —where it promotes neural development and provides neuroprotection in neurodegenerative diseases such as Alzheimer’s disease (AD) 20 and Parkinson’s disease (PD) 22,23 —we sought to investigate its potential protective mechanisms in NMOSD
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