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In a survey of UK HCPs, for example, awareness of semaglutide and tirzepatide was high among specialists, including diabetologists, endocrinologists and cardiologist, whereas for more than 50% of primary care physicians surveyed the much older, less effective orlistat was top of mind [7]

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that is, when pharmacokinetics are “linear.” In this situation, when the drug is eliminated (ie, metabolized and excreted from the body), the fall in blood level is proportionate to the concentration of the drug in blood