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β -Arrs were shown to interact more transiently with β 1 -AR than β 2 -AR in response to agonist-stimulated cells, possibly due to weakened phosphorylation of β 1 -AR, which in turn will make the interaction of β -Arrs with the β 1 -AR too weak to recruit ubiquitinating enzymes (Liang and Fishman, 2004)
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