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NNMT inhibition or NNMT knockdown significantly increases energy expenditure, reduces body weight and white adipose mass, improves insulin sensitivity, and normalizes glucose tolerance and fasting blood glucose levels

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Although the positive ion constant neutral loss ion scanning indicated ions of both m/z 458.3 and m/z 461.2 (ΔM = 3), the relative abundances of these two signals were 100% and 48%, respectively (Table 1), which is inconsistent with the equal abundances of conjugates that would be formed by reaction of an electrophilic metabolite with equimolar GSH and labeled GSH